Job Description Vertex Pharmaceuticals is seeking a Contract Research Scientist to join the Chemical Biology group. We aim to treat serious diseases, many with targets difficult to drug. In this lab-based role, this scientist will help deploy novel covalent drug discovery techniques to the identification and validation of ligands for hard-to-target proteins. The ideal candidate is a motivated, detail oriented, life-long learner with expertise in covalent drug discovery and compound screening. Key Duties and Responsibilities: High throughput compound screening Designing, executing and troubleshooting novel screening approaches for covalent ligand discovery Proactive verbal and written communication to effectively engage with scientists from different disciplines on the team. Collaboratively work with members of the team to coordinate screening staging and timing Knowledge and Skills: Expertise in covalent chemoproteomics and data analysis Knowledgeable about concepts of compound binding affinity, selectivity, reactivity and kinetics Automation for liquid handling Affinity capture methods including immunoprecipitation Western analysis Cell biology (cell culture, lentiviral based expression) Pay Range: dependent upon experience #J-18808-Ljbffr Vertex Pharmaceuticals
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Are you a proactive, creative problem solver who enjoys working with facts and data? Do you need variety and change to keep from getting bored? Once youve been trained, do you prefer to work independently and get things done? Do you agonize over details and make sure ...